Lancaster is an expensive residential neighbourhood in Algonquin, Liberty City. It is bounded by Middle Park East along Quartz Street to the south, Middle Park along Columbus Avenue to the west, East Holland along Topaz Street to the north and by the Humboldt River to the west. The neighbourhood comprises of medium rise, expensive apartments, which are mainly inhabited by Downtown businesspeople. One of the girlfriends that Niko can meet, Alex Chilton lives in a rich apartment in Lancaster. A Terroil filling station is located on Albany Ave, Lancaster. In 2008, Lancaster had a estimated population of 2,483.
- Lancaster's subway station is the Quartz East station, located at the intersection of Albany Avenue and Quartz Street. It is served by the Algonquin Outer Line.
- One of the city's most important bridges, the East Borough Bridge has its Algonquin access in Lancaster. The bridge can be accessed from Ruby Street, at the intersections with both Bismarck and Albany Avenues.
- One of two branches of the high end restaurant, the Superstar Café is located in Lancaster, along Bismarck Avenue between Ruby Street and Quartz Street. The other branch belongs to Star Junction in the heart of the city.