The hospital is one of two major health facilities in Los Santos, the other being County General Hospital further east in Jefferson; players who die on the western half of Los Santos are more likely to respawn at All Saints General. Unlike County General Hospital, All Saints General is based in a modern structure in a more affluent portion of the city. Also, a knife can be found in the back. The hospital has an ambulance, which can be used to complete the Paramedic side mission. The hospital is loosely based on the Cedars-Sinai Medical Center.
- The name of the hospital is an obvious reference to a popular medical TV drama All Saints, which was very popular in Australia, its country of origin, and the United Kingdom, where Rockstar hails from. Despite All Saints' popularity overseas, it never reached the United States.