|Amanda De Santa|
|Full Name||Amanda De Santa|
|Aliases||Amanda Townley (former name)|
|Home||Rockford Hills, Los Santos, San Andreas|
Michael De Santa (husband)|
Jimmy De Santa (son)
Tracey De Santa (daughter)
|Voiced by||Vicki Van Tassel|
In 2004 Amanda, Michael and their two children were forced to enter the witness protection program after Michael was caught during a robbery in Ludendorff, North Yankton. The two moved to Los Santos although their relationship became strained. She eventually became a financial burden on her husband through her shopping leading Michael to return to a life of crime.
In Marriage Counseling, Michael finds her wearing a towel in the upstairs hallway and storms into their bedroom where he finds their tennis instructor Kyle Chavis in his underwear. In a rage, he chases Kyle down with his gardener's truck and pulls his house down from the cliff, only to realize that it belonged to the mistress of Mexican gangster Martin Madrazo (this, among other things, lures Michael back into robbery). In The Good Husband, Amanda reluctantly calls on Michael for help when she is arrested for shoplifting (the player can choose whether or not to save her).
In Did Somebody Say Yoga?, he agrees to practice yoga with Amanda and her instructor Fabien LaRouche. Michael becomes irate when one of their yoga poses resembles a dry hump, attempts to push Fabien in the pool, lands in it himself, and Amanda breaks up with him on the spot. Immediately after, he takes Jimmy to meet his drug dealer at Burger Shot; Jimmy takes the opportunity to trick Michael into drinking purple drank, steal his car and leave him behind. Jimmy distorts the situation to Amanda, causing her to take him and Tracey and leave Michael completely alone in their Rockford Hills home.
Amanda and her children live with Fabien for a short while, but while Fabien is described as an "ideal sexual partner", Amanda quickly bores of his pretentious personality. Tracey and Jimmy also dislike him, and a visit from Jimmy spurs Michael into winning Amanda back. He confronts them at a Bean Machine cafe, where Amanda is so dissatisfied with Fabien that she requests of Michael to "just hit him, please!". Michael knocks Fabien onto the floor with a nearby woman's laptop, and after Michael reclaims Tracey from Lazlow Jones, they reunite and agree to family therapy. After a "cathartic" screaming match in front of Dr. Friedlander, Amanda emerges ready to move back in with Michael. After Michael crosses Devin Weston by releasing his film Meltdown, Weston sends Merryweather mercenaries to assassinate his family. Michael successfully defends Amanda and Tracey from Weston's goons; however, Amanda and the children are forced to move out again for their safety.
- The license plate of Amanda's Sentinel reads "KRYST4L".
- Amanda was a stripper before she met Michael, according to a story told to Wade by Trevor during the trip to Los Santos.