Chatterbox FM is a radio station owned by Donald Love's Love Media. It is hosted and produced by Lazlow (who also co-wrote the script along with Dan Houser). Chatterbox FM is the only radio station in the game which does not feature music; like talk radio stations in the real world, Chatterbox features a format in which listeners call in with opinions, concerns, and complaints, and the host responds with their take on the situation. The station also features two long interviews with Liberty City characters — one with the pacifist, organic food-eating martial artist Reed Tucker, and one with the "cheap pimp from upstate", Fernando Martinez (who would become a recurring character in the GTA series, on- and off-radio). Chatterbox FM is the Triads' favorite radio station.
The callers and calls include a man calling to tell Lazlow that he needs a nanny to spank him (a call so popular it would spawn a similar call about witches in Grand Theft Auto: Vice City, and even its own commercial in Grand Theft Auto: San Andreas); a man calling in regard to taxes (which he pronounces like "Texas"); Toni Cipriani calling with an embarrassing story about his mother; a man who hates clothes ("Does a lion wear clothes? And the lion is the king of the jungle!"); and Maria Latore calling regarding relationship troubles with her boyfriend, Claude (the mute protagonist of GTA III; Maria complains that "he don't talk much").
One caller calls in to talk about turnips, and Lazlow responds, "This isn't 'Gardening with Maurice'". "Gardening with Maurice" would later be heard on WCTR in GTA San Andreas, a game set nine years before GTA III.
One of the calls is from a SPANK addict; he refers to Lazlow as a pansy, and rants about conspiracies and government brainwashing involving toothpaste.
One of the callers mentions killer bees, saying that they will "take over"; another caller to Chatterbox said the same thing in GTA Liberty City Stories, a game set three years before GTA III. The caller in GTA Liberty City Stories says that honey is "bee shit", and that killer bees will come.
A caller who indicates he is fond of eating animals of any kind says he sometimes finds pigeons that have notes attached, commenting "it's like a fortune cookie with wings". Another caller, a woman from "Citizens Raging Against Phones" (C.R.A.P.), a pressure group against the use of telephones, declares that the group uses carrier pigeons in the place of telephones, but that they keep going missing, implying that these are the pigeons the prior caller is eating. In Grand Theft Auto: Liberty City Stories, the predecessor to C.R.A.P. was Citizens United Negating Technology, and its caller to Chatterbox warns that they will first shut off "the internet, then we're going after the phones."
Reed Tucker is a guest on Chatterbox. It is said by both Lazlow and Reed that he has a food market ("Now and Zen") in Trenton, but none exists in the game. After the Reed Tucker conversation a caller yells at the end of the call "free Kevin!", reference to infamous computer hacker Kevin Mitnick. Reed appears on talk radio again in GTA San Andreas, making a comment about masticating that the show's host interprets as masturbation due to Reed's lisp.
The replies Lazlow gives to his callers are usually comically caustic and opinionated. A common reply to nonsense callers is "Well I'm sure that's a lesson to us all." Lazlow off-handedly mentions that he is only hosting Chatterbox because he "got kicked off the rock station"; he is heard hosting V-Rock in GTA Vice City and Grand Theft Auto: Vice City Stories (with Cousin Ed). When he first takes the Chatterbox job in 1998, he is referred to as the host "run out of both Vice City and San Andreas."
The guests on the station were voiced by: Lucien Jones, Karin Bykowski, Hank Stewart, Abbi Davis, Mellowvision.com, Paul Maloney, bernieS, Frank Fava, Kit Halsted, Joe Casalino, Dan Houser, Jay Crutcher, Frank Chavez, DJ Rush, A.M. Watson, Laura Bykowski, Navid Khonsari, Sherry Wohglmuth, Porkchop, Renaud Sebbane, Kyle Maclachlan, Sabby, Kim Schaefer, Debi Mazar, Nick Mandelos, David Connell, Reed Tucker, Jennifer Kolbe, Ami Plasse, Keith Broadus, Cameo Carlson, JD Leeds and Michael Madsen
In GTA Liberty City Stories, which is set three years before GTA III, Lazlow's callers are diverse but generally offensive, including someone who wants to knock down the Liberty City cathedral, a gothic girl wanting to cast spells on Lazlow, a foul-mouthed cannibal who asks why he can't eat people, a man obsessed with shaving, a 7-year-old boy with a very foul mouth, and a man complaining about Vinewood ("if I see one more damn movie with ten kids, a dog in a wheelchair and some damn baseball championship. I'm going to start killing people and blame it on Vinewood"). Ma Cipriani, the mother of the game's main character, also calls in, but gets angry with Lazlow, calling him Lazarus, and threatening him with a Mafia assassination. This is a homage to GTA III, wherein Toni calls Lazlow explaining how much his mother controls his life.
In Grand Theft Auto IV, when Lazlow is first mentioned on the radio, raising funds for his new radio project, Integrity 2.0, he is referred to as the host of the "long-defunct Chatterbox FM". Note that the storylines of the GTA III Era and GTA IV are not related, meaning Lazlow has hosted Chatterbox FM in both games' timelines.