The Don is the leader of a mafia family who makes the decisions and leads the family. They are the most powerful and most highest ranked out of all every member of the Mafia. They are often advised by their Consigliere, or advisor. Most Dons act as one of the mission bosses in each of the Grand Theft Auto games.
- Sonny Cangelosi (Gambetti Family, until 1978)
- Jon Gravelli (Gambetti Family, 1978 - 2008)
- Don Pavano (Pavano Family, until 1990)
- Mary Valvona (Pavano Family, 1990 and onwards)
- Vincent Lupisella (Lupisella Family)
- Harvey Noto (Messina Family)
- Giovanni Ancelotti (Ancelotti Family, 1978 and onwards)
- James Pegorino (Pegorino Family, until 2008)
James "Jimmy" Pegorino, former Don of the Pegorino Family.