Ernesto Lopez is the oldest son of Adriana and Mr. Lopez, and the oldest brother of Luis Fernando Lopez and Leta Lopez-Wilkinson. He was abandoned by his father along with brother and sister. Ernesto dislikes Luis, believing that he is drug dealing trash. He moved out of the city and got a family, and a job as an accountant. His siblings dislike him, believing he is a prick, as he apparently never sends money to his mother. Luis makes fun of his wife too. It is revealed that Ernesto only phones their mother twice a year.
- Whenever Luis get drunk alone in either Maisonette 9 or Hercules, he will drunkenly mention that Ernesto is a asshole.
- During one of the Club Management side missions, Dessie asks Luis to go pick up the Blue Brothers and bring them back to Maisonette 9. Luis complies, but states he's only doing so because his niece is crazy about them. Considering the fact the Ernesto and Luis hardly talk, and that his kids think their uncle Luis is dead, it can be implied that it is actually Leta's children he is talking about.