FlyUS is a prominent airline featured in Grand Theft Auto IV. Its slogan is: "Live a little, Fly with US". The Boeing 747 Domestic is the only known jet used by the Airline. At Francis International Airport, there are many airlines promoting flights to Los Santos & Las Venturas as well as FlyUS cars driving along such as the Feroci and the Perennial aswell as the Ripley and the Airtug. But there are also driving Taxi's and Busses The airline's livery appears to be based off of the previous generation United Airlines, though the name could be a joke towards US Airways. A company named FlyUs exists in real life, however it is not a passenger airline, but the logo does bear a stunning resemblance to it.
The name could be trying to say 'fly us', sexual slang for having sex with them.