The Colombian Cartel are a Colombian drug cartel led by Miguel and Catalina. First arriving in 1998, they quickly gained control of parts of Staunton Island and Shoreside Vale. They are heavily involved in the drugs trade and are known to deal with the Uptown Yardies. Their main enemies are the Leone Family and the Yakuza.
The Diablos are a Puerto Rican small street gang led by El Burro and are based in Hepburn Heights, Portland. They arrived in 1998 but, due to their limited fire power, could only gain control of one district. Three years later, the gang still has limited fire power, however, they continue to hold onto Hepburn Heights. Their enemies are the Leone Family, Triads, Uptown Yardies and Yakuza.
The Forelli Family, possibly led by Mike Forelli, is the smallest organization in Liberty City. In the 1980s the Forelli Family had been a major force in the city, but during 1998 saw their influence greatly reduced due to Toni Cipriani and the Leone Family. By 2001, their only territory is Marco's Bistro in Saint Mark's. Their enemies are the Leone Family, Uptown Yardies, Southside Hoods & Yakuza.
Led by Salvatore Leone, the Leone Family have been a force in Liberty City longer than any other gang. They are based on Portland, in particular Saint Mark's, but also have interests in the Red Light District, Chinatown and Trenton. They had previously controlled more of the city, but in 1998 saw their influence greatly reduced.
The Southside Hoods are an Afro-American street gang led by D-Ice and are based in the poorer areas of Shoreside Vale. They arrived in the city in 1998, however divisions began to show. Differences began to show and the gang split into two sub divisions, the Red Jacks and the Purple Nines. Despite their differences, they continue to work together. Their main enemies are the Forelli Family & the Columbian Cartel.
The Triads are a Chinese criminal organization that arrived in the city in 1998, with help from the Sicilian Mafia. They control the Chinatown area of Portland and are the enemies of the Leone Family. The leader of the Triads is unknown and are involved in many criminal activities.
The Uptown Yardies are a Afro-Caribbean criminal organization led by King Courtney, based on Staunton Island. Their rivals are the Diablos, and are known to deal with the Colombian Cartel. They arrived in the city in 1998, and took control of some if the Forelli Family's territories, but have limited influence.
The Yakuza are a Japanese criminal organization based on Staunton Island. Since they arrived in Liberty City in 1998, their influence has fallen but are still a prominent force in the city. They are led by Asuka and Kenji Kasen. Their main enemies are the Leone family, Uptown Yardies, Diablos, Colombian Cartel & the Forelli Family.