As its name implies, the hospital is situated in southeast Lancet, Algonquin, Liberty City, consisting of a large building occupying a entire city block bordered by Jade Street, Albany Avenue, Kunzite Street (part of the Algonquin Bridge onramp) and Bismarck Avenue. Like most other hospitals, the building lacks an interior (being insignificant to the development of the game's storyline), but spawns Ambulances on the Bismarck Avenue side, and also includes a health pack on the eastern entrance of the south side, as well as ECola vending machines in its entrances. The hospital also features a heliport (accessible only by air), as well as a tall smokestack.
- The name of the hospital is identifiable over the arched western entrance on the south side of the building, with the hyphen between "Lancet" and "Hospital" included within the name. In addition, a subtitle that reads "St. Openshaw" accompanies the Lancet-Hospital Center signage.
- The Lancet-Hospital Center is a perfect place to start a massacre and gain the "One Man Army" Achievement. To do this, the player has to gain a six star wanted level, either by killing the people outside and inside the hospital and destroying vehicles, or by typing in the "Gain One Star Wanted Level" cheat six times. Once the player has obtained the six star wanted level, hide at the back of the hospital. If any police officers come for you, just kill them. Keeping this up for five real-world minutes will give the player the achievement. If the player does run low on health, they can pick up the Health pack provided or they can drink coke from the eCola Vending Machine or they can enter the parked ambulances (although they do not fully restore the player's health), therefore staying alive.