The following is a list of missions featured in Grand Theft Auto IV. For a list of missions in The Lost and Damned and The Ballad of Gay Tony, see Missions in The Lost and Damned and Missions in The Ballad of Gay Tony.
In the game, many missions are available to do at the same time from multiple characters, so this list does not reflect any required chronological order of completion. Each character's respective missions, however, can only be completed in the order listed. And, of course, some characters and their respective missions may not be unlocked until certain missions are completed. The list is done in a logical order in which it can lock chronologically with The Lost and Damned and The Ballad of Gay Tony.
In total, there are 91 main missions. Which are the following:
|Spoiler Warning: Plot and/or ending details are in the text which follows.|
- The Cousins Bellic - Drive to Roman's place.
- It's Your Call - Drive Roman to the hardware store and lose the loan sharks.
- Three's a Crowd - Pick up Mallorie and Michelle from the subway station, drive them to Michelle's place and go buy new clothes at the Russian Shop.
- Bleed Out - Save Roman from the Albanian loan sharks and beat up Bledar Morina, Kalem Vulaj and Dardan Petrela.
- First Date - Take Michelle bowling.
- Easy Fare - Drive Jermaine Andrews to the lockup and lose the cops.
- Jamaican Heat - Pick up Little Jacob, watch over the meeting and kill the gang members.
- Bull in a China Shop - Smash the shop's window to scare the owner into paying his debts and take the money to Vlad.
- Hung Out to Dry - Chase the laundromat owner by car and force him to pay his debts.
- Clean Getaway - Travel by train to steal a car, then go to the car wash and drive it over to Vlad's lockup.
- Ivan The Not So Terrible - Kill or spare Ivan Bytchkov.
- Concrete Jungle - Drive Jacob to a drug deal and kill the dealers.
- Crime and Punishment - Search vans for TVs and drive the right van to the lockup.
- Do You Have Protection? - Threaten Joseph Kaplan and his associates, reclaim the money and go to the gun store.
- Shadow - Follow and kill the dealers.
- No Love Lost - Chase and take out Jason Michaels and the other Lost MC bikers.
- Rigged to Blow - Drive a truck filled with explosives to the garage.
- The Master and the Molotov - Kill Mikhail Faustin.
- Russian Revolution - Go to meet Dimitri, wipe out Bulgarin's men and escape from the cops.
- Escuela of the Streets - "Clean" the streets from drug dealers.
- Street Sweeper - "Clean" the dealers from a car.
- Luck of the Irish - Protect Packie McReary with a sniper rifle.
- Blow Your Cover - Escape from an attempted LCPD drug bust and drive Playboy X back to his penthouse.
- Search and Delete - Get a cop car, use the police computer to find and kill Lyle Rivas.
- Easy as Can Be - Drive Brucie's car back to him with as little damage as possible.
- Out of the Closet - Make a date with French Tom online and kill him.
- No. 1 - Retrieve Stevie's car and win a street race.
- The Puerto Rican Connection - Follow the train and kill Manny's buddies who made fun of him.
- Call and Collect - Identify the blackmailer, kill him and take the pictures to Francis.
- Harboring a Grudge - Steal a truck and drive it safely to the lockup.
- Waste Not Want Knots - Steal the money, kill all attackers and escape with a boat.
- Three Leaf Clover - Rob the bank and escape from the cops.
- Final Interview - Get into a job interview, retrieve the files and kill Goldberg.
- Holland Nights - Kill or spare Clarence Little.
- Lure - Lure the dealer to firing range and shoot him.
- Actions Speak Louder than Words - Plant a bomb onto Tony Black's car and kill him and his goons.
- I Need Your Clothes, Your Boots, and Your Motorcycle - Chase and kill Frankie Garone.
- Ruff Rider - Gun down Jayvon Simson, the man who ratted Dwayne.
- Undress to Kill - Reclaim The Triangle Club back for Dwayne.
- Hostile Negotiation - Rescue Roman from a kidnapping operation.
- The Holland Play - Kill either Playboy X or Dwayne Forge.
United Liberty Paper
- Wrong is Right - Chase and kill Oleg Minkov.
- Portrait of a Killer - Locate and kill Adam Dimayev.
- Dust Off - Follow a helicopter, kill its occupants and fly it back to Francis International.
- Paper Trail - Use the stolen helicopter to kill Eduard Borodin with the assistance of Little Jacob.
- Smackdown - Chase Bucky Sligo, then kill Bucky and his crew.
- Babysitting - Protect Kim Young-Guk's boat and kill any attackers.
- Tunnel of Death - Barricade the Booth Tunnel, steal the prison transport containing Aiden O'Malley, lose the cops and kill O'Malley.
- Taking in the Trash - Collect the diamonds hidden in the trash and return to the sanitation depot.
- Meltdown - Chase and kill Luca Silvestri and his gang.
- Museum Piece - Kill Mafia or Jewish Mob members and escape from the Museum.
- No Way on the Subway - Chase and kill the two bikers.
- Late Checkout - Kill Issac Roth, his guards and his two associates.
- Weekend at Florian's - Find Florian's place.
- I'll Take Her - Kidnap Grace.
- Ransom - Take Grace's picture and send it to Packie.
- She's a Keeper - Drive Grace to a new safehouse.
- Hating the Haters - Kill the homophobe.
- Union Drive - Chase and kill the blackmailers.
- Buoys Ahoy - Chase and kill Dimitri's men.
- Catch the Wave - Kill all the Russians and defend Phil.
- Trespass - Kill Chubby Charlie and all the attackers.
- To Live and Die in Alderney - Escape from the police and protect Phil.
- Diamonds Are a Girl's Best Friend - Drive to the hostage exchange and kill all of Bulgarin's men.
- Dining Out - Kill Kim Young-Guk and his guards.
- Liquidize the Assets - Kill the guards and destroy all the vans.
United Liberty Paper
- If the Price is Right - Kill all the goons with Phil.
- Mr and Mrs Bellic - Go to the wedding.
- A Revenger's Tragedy - Kill Dimitri and Pegorino's goons
- Sixaxis Tutorial (PS3 only)