In 1998, under the leadership of Salvatore Leone's elderly uncle, the Sicilian Mafia sparked several wars between rival families in Liberty City in the hope of controlling the city once the previous families had destroyed each other.
Their plan was foiled, however, when Salvatore Leone and his Caporegime, Toni Cipriani, were able to hold their own against all of the other criminal organizations in the city. To retaliate, the Sicilians attempted to intimidate the mayor into convicting Leone on racketeering charges. This strategy was never fully executed due to the fact that Cipriani, under orders from Salvatore, killed Massimo Torini. After this, Salvatore's uncle acknowledged defeat and the Sicilian Mafia left Liberty City. When his nephew began to insult him after their final confrontation, he simply replied, "Every dog has his day". Three years later Salvatore Leone is, in fact, killed by Claude.