Giggle Cream is a dessert topping mentioned in Grand Theft Auto: Vice City and Grand Theft Auto IV. The topping is a mixture of whipped cream and nitrous oxide (commonly known as "laughing gas", hence the name). The product is advertised on the radio in GTA Vice City with the tagline "Makes dessert funny". Vice City Congressman Alex Shrub has pushed a bill that allows the manufacture and sales of Giggle Cream. Giggle Cream is lethal and has killed 23 people<ref>From the radio station VCPR (1:21:47):
Maurice Chavez: "And up on Capitol Hill, you were instrumental in pushing through a bill allowing the manufacture and sale of Giggle Cream, a dessert with potential lethal consequences."
Alex Shrub: "Not true, only 23 people have died and several of them probably deserved it."</ref>, leading to a ban by the FDA in 1987<ref>Timeline & Events. Kent Paul. official Kent Paul website</ref>. In GTA IV, it can be seen being sold illegally on www.yourmexicandoctor.com.
- Giggle Cream advert – The Advertising Council on Rockstargames.com