Vespucci University is a prestigious university in Varsity Heights, Algonquin, Liberty City based off of Columbia University. The university is likely named after an early European explorer of the Americas, Amerigo Vespucci. This again mirrors Columbia University, as it is similar in name to Christopher Columbus, another early European explorer of the Americas.
In The Ballad of Gay Tony, Luis Fernando Lopez must drive his friend Al Di Napoli to a drug deal with Oscar Gomez and another unknown accomplice at the university. During the mission, the deal is ambushed by police, and winds up with the four escaping.
The Higgins Helitours' pilot describes Vespucci's library as the place "where they get their long hair stuck in their fancy books."
Brian Meech graduated from Vespucci University.