The Don is the leader of a mafia family who makes the decisions and leads the family. They are the most powerful and most highest ranked out of all every member of the Mafia. They are often advised by their Consigliere, or advisor. Most Dons act as one of the mission bosses in each of the Grand Theft Auto games.
- Salvatore Leone (Leone Family, mid-1980s to 2001)
- Franco Forelli (Forelli Family)
- Sonny Forelli (Forelli Family, until 1986)
- Paulie Sindacco (Sindacco Family, until 1998)
- Uncle Leone (Sicilian Mafia)
- Sonny Cangelosi (Gambetti Family, until 1978)
- Jon Gravelli (Gambetti Family, 1978 - 2008)
- Don Pavano (Pavano Family, until 1990)
- Mary Valvona (Pavano Family, 1990 and onwards)
- Vincent Lupisella (Lupisella Family)
- Harvey Noto (Messina Family)
- Giovanni Ancelotti (Ancelotti Family, 1978 and onwards)
- James Pegorino (Pegorino Family, until 2008)
James "Jimmy" Pegorino, former Don of the Pegorino Family.