Based off of New York City's Pier 17 Pavilion at the South Street Seaport, Pier 45 is a converted pier and pavilion containing different types of restaurants and shops (not to be confused with advertising boards hung along parts of the building's corridor that include brand names such as Gnocchi, Memory Lanes and Rimmers). Pier 45 is a must see for tourist, offering great views of the Humboldt River and the Broker Bridge. The interior cannot be accessed, but there is an upper level area with picnic tables that can be accessed, which includes two Sprunk vending machines and a health pick-up.
In GTA IV, three missions directly involve the pier - Buoys Ahoy, Sara's 2nd random encounter, and the Most Wanted assignment on Simon Nashly. In The Ballad of Gay Tony, the upper level of the building is the location of Margot's second random encounter.