The HPV-1000 is a Police bike available in Grand Theft Auto: San Andreas. It is very fast and agile, although the player can fall off easily if they have minimal "bike skill". Unless the Rhino or Hunter is available, this bike is a good choice for completing the Vigilante side mission - mainly because the player can fire a submachine gun straight ahead, allowing them to take out the opponent easily. The sirens divert traffic only if it is directly in front of the bike, as it can usually slip round the side of vehicles, unlike patrol cars. It is a unique model that isn't shared by another motorcycle, it looks similar to a police Kawasaki KZ-1000.
The name may be a reference to the human papillomavirus (HPV).