Grenades are highly destructive to both people and objects, including vehicles — in most GTA games, conventional vehicles can be destroyed with a single grenade, and people will almost always be killed if within the blast radius. Grenades are ideal for taking out enemies hiding behind cover, and for scattering tight-knit groups of foes. In GTA III, GTA Vice City, GTA San Andreas and GTA Liberty City Stories the grenades are based on an M67 grenade. In GTA IV they are based on the M26A1 frag grenade. The the GTA Vice City Stories and the GTA Chinatown Wars models remain unidentified.
Grenades can, of course, be just as dangerous to the player as to enemies, and must be deployed carefully to avoid the grenade bouncing back to the player. In Grand Theft Auto IV, the player can drop a live grenade to the ground, but must run for cover before it detonates. One can also 'cook' a grenade (hold onto it while it counts down) for a short time before throwing it. It begins beeping if it is held for too long, and if not thrown, will explode in the player's hands. In Grand Theft Auto IV, grenades are in fact much more lethal to the player than to enemies -- unless a grenade explodes very close to an enemy, they will likely survive, despite being thrown by the explosion.
In GTA IV, grenades can be dropped while driving, and are more effective for in-car use than Molotovs, due to their far superior radius of effect, however the player must take care to remain on the move while using grenades — the player's own car can easily be caught in the explosion if it does not move on immediately. In multiplayer, a popular tactic is to cook a grenade, then walk up to a group of unsuspecting players and let it detonate; this tactic, called Martyrdom, is useful for killing a large group at the expense of the perpetrator's own life. This is only advised in Free Mode.
Go to the block of houses west of the Russian Mafia headquarters, and enter it from its south side (Azeri Heights) (119 20 2)
Go to the processing plant. Go to the north side and look between the two pairs of water tanks (Blind Eye processing plant) (222,5 7,5 2)
Go to the north section of the road west of the Vedic Temple. You’ll see a passage south of the east tower near the street end. Follow it until its end (Narayana) (238,5 205 3)
Go to the building east of Bayano hospital. Enter from the stairs on its east side, then use the ramp to go up. Use one of the side ramps and jump to the central platform. Jump from the central platform to the one on the east side (Bayano) (67 187,5 5)
Go to the big road north of the construction site. Go to the zone where it turns north near the Vedic Temple. Check the building three squares north of the corner (Petula) (157,5 173,5 2)
In every GTA game with grenades the safety pin is never pulled and the safety lever is untouched in the GTA III Era, but in the GTA IV Era despite an animation showing the pin is pulled but the safety lever and pin are still on the grenade.
In the GTA IV Era grenades beep when there about to explode in your hand which is not possible for any real life hand grenade.